Wednesday 25 January 2012

Solving Pedigrees - Now testing for X-linkage!

Here are those same two pesky pedigrees from before.  In the previous post you had a chance to determine whether the mutant allele was dominant or recessive to wild-type.
 The one above MUST be recessive because two unaffected parents produced affected children.  Now try it with X-linkage.  You can use the symbols Xr and XR to denote a recessive mutant allele and the dominant wild-type allele, respectively.  Here's a solution:


And as for this one, we can't rule out dominant so easily!  Check this for both an X-linked recessive and an X-linked dominant pattern of inheritance.  The solution is below.



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